Web25. jún 2024 · METHODS: In an open-label, 40-week, phase 3 trial, we randomly assigned 1879 patients, in a 1:1:1:1 ratio, to receive tirzepatide at a dose of 5 mg, 10 mg, or 15 mg or semaglutide at a dose of 1 mg. At baseline, the mean glycated hemoglobin level was 8.28%, the mean age 56.6 years, and the mean weight 93.7 kg. WebIndeed such suppression may increase mortality. As noted on Wiki Journal Club, modern ACC/AHA guidelines “do not comment on the use of antiarrhythmic medications in ACS care.” Further Reading/References: 1. Wiki Journal Club 2. 2 Minute Medicine 3. CAST-I Trial @ ClinicalTrials.gov 4. CAST-II trial publication, NEJM 1992 5.
COMET - Wiki Journal Club
Web15. dec 2024 · Wiki Journal Club(WJC) summarizes and reviews landmark studies across medicine and surgical specialties. (More... Browse Like our internal medicine reviews? Get … WebThis was an exploratory, post hoc, non-pre-specified analysis of the TOPCAT (Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function) trial. Subjects with symptomatic HF and a left ventricular ejection fraction ≥45% were randomized to spironolactone or placebo therapy. pro ceramic beauraing
TOPCAT (free version) download for PC
Web10. apr 2014 · Lessons from the TOPCAT Trial NEJM Home Specialties Specialties Allergy/ Immunology Cardiology Clinical Medicine Dermatology Emergency Medicine … Web2. aug 2016 · More recently, spironolactone has been evaluated in the National Heart, Lung, and Blood Institute (NHLBI) sponsored TOPCAT trial 26 in which 3445 patients with chronic HF with a preserved left ventricular ejection fraction (HF-PEF) were randomized to spironolactone in a dosing strategy starting with 15 mg/day with possible up titration to … Web22. nov 2024 · Description: The goal of the trial was to assess the safety and efficacy of finerenone in reducing cardiovascular (CV) events among patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD). Study Design Eligible patients were randomized in a 1:1 fashion to either finerenone (n = 3,686) or placebo (n = 3,666). procergs forticlient