Phosphorylation of irf3 antibody

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August undefined, 2024

WebD, IRF3 phosphorylation is inhibited by E3L. 293T cells were transfected with 10 μg of an IRF3 expression vector and 10 μg of E3L (lanes 3 and4) or K3L (lanes 5 and 6), infected … Web功能: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL.

Anti-phospho-IRF-3 (Ser396) Antibody 07-582-I - EMD …

WebApr 11, 2024 · In the TLR4-TRIF-IRF3-type I IFN signaling cascade, phosphorylation of the TBK1 kinase is a key step 2. Phosphorylated-TBK1 (pTBK1) subsequently phosphorylates IRF3, which then translocates... WebJan 24, 2016 · The IRF3 transcription factor is critical for the first line of defense against pathogens mainly through interferon β and antiviral gene expression. A detailed analysis … gp velocity\u0027s

The TAK1-JNK cascade is required for IRF3 function in the

WebWestern blot analysis of Phospho-IRF3 pSer385 using Phospho-IRF3 pSer385 polyclonal antibody (Product # PA5-36775) at a dilution of 1:500. Lane 1: Hela cell lysate treated with PMA (100nM, 15min), Lane 2: … WebJan 20, 2009 · In this study, we show that another kinase, c-Jun-NH2-terminal kinase (JNK), phosphorylates IRF3 on its N-terminal serine 173 residue, and TAK1 can stimulate IRF3 … WebFigure Legend Snippet: Suppressed DOX-induced phosphorylation of IRF3, TBK1 and p65 was observed by immunoblot analysis following STING knockdown in HL-1 cells following DOX treatment (1 μm for 24 h). Quantitative data represent the relative ratio to total IRF3, TBK1 or p65 ( n = 6) Techniques Used: Western Blot gpvf/operacao/login/loginpage.xhtml

Anti-phospho-IRF-3 (Ser396) Antibody 07-582-I - EMD …

Phospho-IRF3 (Ser386) Polyclonal Antibody - Thermo Fisher Scientific

WebDeficiency of STING prevented IRF3 phosphorylation by ethanol or ER stress, and absence of IRF3 prevented hepatocyte apoptosis. The pathogenic role of IRF3 in ALD was independent of inflammation or Type-I interferons. Thus, STING and IRF3 are key determinants of ALD, linking ER stress signaling with the mitochondrial pathway of … WebMar 5, 2024 · Rnf39 deficiency and knockdown both enhanced RNA virus–induced IRF3 phosphorylation (Fig. 2, A to C, and fig. S3D). Furthermore, ... The cell lysates were immunoprecipitated with Flag antibody and then immunoblotted with the indicated antibodies. The specific bands were marked by asterisk. All experiments were repeated at … gpv group hildesheimWeb该IRF3 Polyclonal Antibody. This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha … gpv group annual report

"WebOverview Product name Anti-IRF3 (phospho S396) antibody See all IRF3 primary antibodies Description Rabbit polyclonal to IRF3 (phospho S396) Host species Rabbit Tested … " - Phosphorylation of irf3 antibody

Phosphorylation of irf3 antibody

Transcription-independent regulation of STING activation and

WebOct 22, 2024 · IRF3 is a transcription factor that participated in type I IFN production, and its function is realized by transposition from the cytoplasm to the nucleus (Vandevenne et al., … WebTBK1-dependent phosphorylation of IRF3 leads to its nuclear translocation and subsequent activation of transcriptional programs that ultimately lead to the production of inflammatory cytokines, ... Staining with a dsDNA-specific antibody showed that such treatment is sufficient to induce cytosolic accumulation of dsDNA (Fig 1J, ...

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WebMar 1, 2024 · The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. WebControl of IRF-3 activation by phosphorylation Interferon (IFN) regulatory factor-3 (IRF-3) is a unique member of the IRF family. Its transcriptional activity is regulated solely by …

WebPhospho-IRF3 (Ser386) Antibody (PA5-78025) in WB Western Blot using Phospho-IRF3 (Ser386) Polyclonal Antibody ( Product # PA5-78025 ). Untreated (–) and treated (+) THP-1 whole cell extracts (30 µg) were separated by 10% SDS-PAGE, and the membrane was blotted with Phospho-IRF3 (Ser386) Polyclonal Antibody ( Product # PA5-78025) diluted … WebSep 25, 2015 · Viral infection activates the transcription factors NF-κB and IRF3, which contribute to the induction of type I interferons (IFNs) and cellular antiviral responses. Protein kinases play a critical role in various signaling pathways by …

WebSTING agonist-28. STING Infection; STING agonist-28 (CF510) is a non-nucleotide small-molecule STING agonist.STING agonist-23 activates STING, increases phosphorylation of STING, TBK1 and IRF3.STING agonist-23 promotes the levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-5 in tumor cells.STING agonist-23 exhibits activity against SARS-CoV … WebIt is now well established that TBK1 is responsible for IRF3 phosphorylation in response to stimulation of several intracellular receptors that induce type-I interferons, including TLR3, …

WebSep 1, 2024 · Published findings and our results show that IRF3 is a transcription factor under the tight control by phosphorylation-dependent post-translational modification. …

WebAnti-IRF3 antibody [IRF35I218] (ab50772) Datasheet Reviews ( 3) Q&A (4) References (9) Key features and details Mouse monoclonal [IRF35I218] to IRF3 Suitable for: ICC/IF, WB, Flow Cyt Reacts with: Human Isotype: IgG1 You may also be interested in Primary Alexa Fluor® 488 Anti-PSMA antibody [GCP05] (ab187570) gpv group 中国公司WebThe induction of phosphorylation of STING on S366 of IRF3 on S396 was inhibited in T404E compared to WT or ... T404A, or T404E STAT2 were treated with cisplatin for 24 h. The … gpvh 40 100 owners manualWebPolyclonal Antibody Services; Monoclonal Antibody Services; Anti-idiotype Antibody Services New! Antibody Production Services; Specialized Antibody Services ... Hantavirus GnT Elements Mediate TRAF3 Binding and Inhibit RIG-I/TBK1 directed IFNβ Transcription by Blocking IRF3 Phosphorylation. J Virol.. 2014-01; VS Matthys, V Cimica, N Dalrymple ... gp vehicleWebProtein Mutation Frequency in Cancer. The 'lollipop plot' above illustrates recurrent (observed in 3 or more out of 4440 TCGA tumor samples from 15 cancer types) and … gpv growthWebMAP3K8 mediates the phosphorylation and repression of IRF3 homodimers to promote greater transcriptional activity through utilization ... More The induction of the intrinsic antiviral defense in mammals relies on the accumulation of foreign genetic material. gpvinylsiding.comWebNational Center for Biotechnology Information gpv group thailandWebAug 16, 2024 · Phosphorylated IRF3 dissociates from the STING complex and translocates to the nucleus to induce transcription of innate immune effector genes, such as type I IFNs and proinflammatory cytokines... gpvhoso atx mid tower gaming pc case