High dose statins in elderly

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August undefined, 2024

Web19 de dez. de 2024 · The MIRACL study looked at the effects of a high dose of Lipitor on 3086 patients in the hospital after angina or nonfatal MI and followed them for 16 weeks. 37 According to the abstract: ... My … WebNational Center for Biotechnology Information

Treatment with Statins in Elderly Patients - PubMed

Webthere seems no controversy in initiation of statins in patients for primary prevention up to 80 years of age. Elderly people are at highest risk of cardiovascular morbidity and mortality, … Web1 de out. de 2024 · It is well established that statins reduce adverse cardiovascular outcomes but it remains unclear whether this reduction applies to older adults. Although older individuals have the highest absolute risk for atherosclerotic cardiovascular … small led flashlight ebay

Improving Statin Tolerance in Elderly Patients

Web3 de abr. de 2024 · Importantly, however, the combination of moderate-intensity statins and ezetimibe was associated with lower rates of intolerance-related drug discontinuation or … WebFor primary prevention of CVD, high-intensity statin treatment (atorvastatin 20 mg daily) should be considered in people (without the need for a formal risk assessment): With … Web12 de abr. de 2024 · Moderate-intensity statin with ezetimibe combination therapy was associated with lower rates of intolerance-related drug discontinuation or dose reduction among patients aged ≥75 years (2.3% vs. 7.2%; p = 0.010) and those aged <75 years (5.2% vs. 8.4%; p < 0.001) (p for interaction = 0.159). Median LDL-C levels were 58 mg/dL in … high-order information matters

2024 ACC/AHA Guideline on the Primary Prevention of …

Cholesterol Management: ACC/AHA Updates Guideline AAFP

WebNHS medicines information on atorvastatin – what it's used for, side effects, dosage and who can take it. WebRisk increased with increasing dose of statin from the hazard ratio of 1.17 (95% CI 0.84-1.65) for the lowest dose to 1.51 (95% CI 1.14-1.99) for the highest dose. Conclusion: The dose-response for statins on new onset of diabetes suggests elderly women should not be exposed to higher doses of statins. high-order networkWeb23 de out. de 2015 · While the Study Assessing Goals in the Elderly (SAGE) showed similar efficacy of higher-intensity statins, it also showed greater clinical risks. The 893 older adults with CAD and ischemia enrolled in SAGE were randomized to atorvastatin-80 mg versus pravastatin-40 mg. Higher-dose statin therapy was associated with 23% reduced … high-order interleaving

"Web30 de out. de 2024 · The incidence and prevalence of atherosclerosis increase with age and the number of cardiovascular events is higher in elderly patients. The most efficient … " - High dose statins in elderly

High dose statins in elderly

Statins and the elderly: recent evidence and current indications

Web2 de fev. de 2024 · High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006; 355: 549-559. Crossref; PubMed; Scopus (2332) ... Benefits of statins in … WebThe USPSTF concludes with moderate certainty that initiating use of low- to moderate-dose statins for the prevention of CVD events and mortality in adults aged 40 to 75 years without a history of ...

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Web19 de jul. de 2024 · A specific high-dose preparation (4 grams per day of icosapent ethyl or 1800 mg per day of highly purified EPA) has been found to reduce the risk of heart attack, stroke, need for stent of bypass surgery, and cardiac death when used with a statin in people who have mild hypertriglyceridemia (149 to 500 mg/dL) and either established … Web2 de out. de 2024 · Statin drugs have been shown to reduce the risk of cardiovascular disease (CVD) in young and middle-aged adults. With older adults (those 75 and over), …

Web18 de jun. de 2024 · The concentration of LDL cholesterol was 24 mg/dL lower in those taking the higher dose of atorvastatin, and the risk of having a major cardiovascular event was 22% lower ( P <0.001). But there was no significant effect on all-cause death. 3 In the IDEAL trial (Initiating Dialysis Early and Late), the effect of atorvastatin at a dose of 80 … WebInitiate with a lower dose and avoid very high dose or high intensity statins if at increased risk of myotoxicity e.g. the elderly, severe renal impairment (eGFR<30), liver …

Web3 de abr. de 2024 · Importantly, however, the combination of moderate-intensity statins and ezetimibe was associated with lower rates of intolerance-related drug discontinuation or dose reduction compared with high-intensity statin monotherapy among patients in the elderly group (2.3% vs 7.2%; P = 0.010) and in those younger than 75 (5.2% vs 8.4%; P … WebManaging hypercholesterolemia and preventing cardiovascular events in elderly and younger Chinese adults: focus on rosuvastatin Zhen Wang, Junbo GeDepartment of Cardiology, Zhongshan Hospital, Shanghai, People's Republic of ChinaAbstract: Coronary heart disease (CHD) is the leading cause of death worldwide. The efficacy and safety of …

WebThe initial dose and any dose increments should be carefully chosen in elderly and in patients with cardiac symptoms, diabetes mellitus or insipidus: too high initial dose or too rapid increase may cause or aggravate symptoms of angina ... antidiabetics dose remains unchanged. Statins Reports indicate that some HMG-CoA reductase ...

Web14 de abr. de 2024 · In the IMPROVE-IT trial, researchers showed adding ezetimibe to moderate-intensity statins vs. moderate intensity statin alone in ASCVD patients resulted in lower LDL cholesterol levels and reduced ASCVD events, especially in those older than age 75 years. 1 However, most guidelines recommend high-intensity statin therapy for … small led clockWeb29 de out. de 2024 · That's due to a lack of studies assessing the safety and effectiveness of statins for people in this age group. "There are no clear guidelines after 75,” says cardiologist Dara Lee Lewis, M.D., an associate physician and instructor in medicine at Brigham and Women's Hospital in Boston. “And it has been difficult as a provider, … small led flashlightWebOverall, myopathy occurred in approximately 0.1% to 0.2% of patients who received statins in clinical trials. 23 The rate of CK elevations greater than 10 × ULN reported in phase 3 clinical trials of cerivastatin was significantly greater than that of other statins and was dose dependent (placebo, 0.0% [n = 198]; 0.4 mg/d, 1.0% [n = 194]; 0.8 ... small led flashlights amazonWeb3 de mar. de 2024 · Mechanism of action. The beneficial effects of statins result, at least in part, from direct inhibition of HMG-CoA reductase. Citation 8 This inhibition reduces endogenous cholesterol biosynthesis and increases the expression of LDL receptors responsible for LDL-C uptake and clearance. Citation 8 These do not seem to be the … small led downlightersWeb3 de mai. de 2024 · The recommended dose is: 30. Five-year CVD risk 5–15%: 10–20 mg atorvastatin (max 80 mg daily) Five-year CVD risk > 15% (including those with known CVD): 10–40 mg atorvastatin (max 80 mg daily) It is recommended to monitor non-fasting lipids every six-to-twelve months until the desired target is reached. small led filament light bulbWeb17 de mar. de 2024 · The dose response and tolerance should be assessed in about 6-8 weeks. If LDL-C reduction is adequate (≥30% reduction with intermediate- and 50% with high-intensity statins), regular interval monitoring of risk factors and compliance with statin therapy are necessary to determine adherence and adequacy of effect (about 1 year). small led globes high-order spectral analysis toolbox