Ctgf gene card

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August undefined, 2024

WebExpression of CTGF and Cyr61 in colorectal cancer Upregulation of Cyr61 and CTGF gene expression in colorectal cancer suggests they have a role in tumour initiation or development. However, the genes are not as highly expressed in advanced stages of colorectal cancer, suggesting their role may be important at an early stage of tumour … WebDescription. Connective tissue growth factor (HGNC Symbol) Entrez gene summary. The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor.

SiRNA in MSC-derived exosomes silences CTGF gene for …

WebAbstract Objectives: To examine expression of the connective tissue growth factor (CTGF) gene in human thyroid cancer and establish whether a correlation exists between the presence of CTGF protein and clinicopathological parameters of the disease. WebIntroduction. Connective Tissue Growth Factor is a part of the CCN family of proteins. The CCN family presently consists of six members in human also known as: Cyr61 (Cystein rich 61), CTGF, Nov (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). CCN proteins are matricellular proteins which are involved in ... my motion benore inventory

1490 - Gene ResultCCN2 cellular communication network factor …

WebAntibodies that detect CTGF can be used in several scientific applications, including Western Blot, Immunohistochemistry, Immunocytochemistry, ELISA and Immunomicroscopy. These antibodies target CTGF in Human, Mouse, Rat, Non-human primate and Bovine samples. Our CTGF polyclonal and monoclonal antibodies are … WebCTGF (also called CCN2), a member of the CCN family of matricellular proteins, has long been known to promote differentiation and proliferation of chondrocytes and osteoblasts (for a review, see Takigawa et al., 2003 ). WebConnective tissue growth factor (CTGF) from basics to clinics Authors Yasaman Ramazani 1 , Noël Knops 2 , Mohamed A Elmonem 3 , Tri Q Nguyen 4 , Fanny Oliveira Arcolino 1 , Lambert van den Heuvel 5 , Elena Levtchenko 2 , Dirk … my mother作文英语

Connective Tissue Growth Factor - an overview

CTGF related genes - GeneCards Search Results

WebApr 4, 2024 · cTGF is highly expressed in Human Epicardial Adipose Tissue and associated with atrial fibrosis, and can be an important risk factor for Atrial Fibrillation . In the human amygdala, CTGF expression was significantly increased in major depressive disorder compared with control subjects. WebConnective tissue growth factor (CTGF), also termed fisp12, β IG-M2, and IGF-BP8, is a secreted cysteine-rich growth factor that belongs to the CCN (cyr61, CTGF, nov) family. It was first isolated in 1991 from serum-stimulated NIH3T3 cells and named fisp12 (fibroblast-inducible secreted protein-12). old newark caWeb结缔组织生长因子（CTGF）是1991年BRADHAM等首先在人脐静脉内皮细胞的条件培养基中发现的，它是一种由349个氨基酸组成,分子量为34～38KD的富含半胱氨酸的分泌肽。中文名结缔组织生长因子简称 CTGF 发现时间 1991年发现者 BRADHAM等属性富含半胱氨酸的分泌肽组成 349个氨基酸分子量 34～38KD 目录 1 物质简介 2 慢性病关系 3 作用 … old newark airport

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Ctgf gene card

Connective tissue growth factor (CTGF) from basics to …

WebJan 7, 2013 · Ctgf is a direct target of mineralocorticoid receptor (MR). A, Schematic representation of mouse Ctgf genomic fragment used for construct. Arrowheads indicate the approximate location of primers used to analyze chromato-immunoprecipitation (ChIP) products. B, Luciferase activity mediated by mouse (−671/+284) Ctgf gene fragment in … WebMar 10, 2024 · CTGF is also known to promote tumor growth in pancreas, prostate, brain, and breast cancer, and to be involved in angiogenesis, metastasis, and drug resistance [ 5, 6 ]. Breast cancer is the most...

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WebConnective tissue growth factor (CTGF) is a newly described 38-kDa peptide mitogen for fibroblasts and a promoter of connective tissue deposition in the skin. The CTGF gene promotor contains a transforming growth factor-beta1 (TGF-beta1) response element. Because TGF-beta1 expression is upregulated … WebCTGF is rich in cysteine and has four modules that make up the extracellular matrix protein. The domains or modules can be divided into the domain that holds the growth factor protein that is similar to insulin, a C-terminal domain that has a cysteine knot, a domain for thrombospondin type 1 and the vWC domain or Von Willebrand type C.

WebMay 10, 2005 · Connective tissue growth factor Gene CTGF Status UniProtKB unreviewed (TrEMBL) Organism Homo sapiens (Human) Amino acids 349 Protein existence Evidence at transcript level Annotation score 2/5 Entry Feature viewer Publications External links History BLAST Download Add Add a publication Entry feedback Function Caution WebCTGF is induced by TGFbeta in diverse cell types, but TGFbeta receptor mediated signaling is impaired in pancreatic cancers and cell lines, usually due to DPC4/Smad4 mutations which arise during the later stages of intraepithelial neoplastic progression.

Web结缔组织生长因子在心肌纤维化中的作用.pdf WebJul 1, 2007 · The CCN2/CTGF is composed of 4 distinct modules: the N-terminal signal peptide for secretion; insulin-like growth factor binding protein-like (IGFBP) module, von Willebrand factor type-C repeat (VWC) module, thrombospondin type 1 repeat (TSP1) module and the C-terminal cystine knot (CT) module. This is consistent with other CCN …

WebCTGF related genes - GeneCards Search Results We’ve updated GeneCards - what’s new in version 5.14 × Free for academic non-profit institutions. Other users need a Commercial license Advanced Home User Guide Analysis Tools Release Notes About Data Access GeneCards Team Log In / Sign Up My Genes No results

WebJul 22, 2002 · Connective-tissue growth factor (CTGF) is a secreted protein implicated in multiple cellular events including angiogenesis, skeletogenesis and wound healing1. It is a member of the CCN family of ... old newark nj photosWebJun 10, 2024 · SiRNA in MSC-derived exosomes silences CTGF gene for locomotor recovery in spinal cord injury rats In conclusion, this study has combined the thoroughness of gene therapy and the excellent drug-loading characteristics of Exo for the precise treatment of SCI, which will shed new light on the drug-loading field of Exo. old newark nj historyWebConnective tissue growth factor (CTGF), also termed fisp12, β IG-M2, and IGF-BP8, is a secreted cysteine-rich growth factor that belongs to the CCN (cyr61, CTGF, nov) family. It was first isolated in 1991 from serum-stimulated NIH3T3 cells and named fisp12 (fibroblast-inducible secreted protein-12). old newark photosWebAbstract. Connective tissue growth factor (CTGF) is a member of the CCN family of secreted, matrix-associated proteins encoded by immediate early genes that play various roles in angiogenesis and tumor growth. CCN family proteins share uniform modular structure which mediates various cellular functions such as regulation of cell division ... old newariWebMar 10, 2024 · CTGF is also known to promote tumor growth in pancreas, prostate, brain, and breast cancer, and to be involved in angiogenesis, metastasis, and drug resistance [ 5, 6 ]. Breast cancer is the most... my motion mdWebMay 8, 2024 · CTGF induced the fibronectin and α-SMA proteins expression in GO orbital fibroblasts. ( A) After treatment of the orbital fibroblasts from GO1 patient with 50, 100, 200 and 400 ng/ml recombinant... my mothr earth poemCTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair, and is critically … old newark airport images