Cisplatin binding protein
WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … WebMar 27, 2024 · Cisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus Cisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus Cancers (Basel). 2024 Mar 27;12 (4):809. doi: 10.3390/cancers12040809. Authors
Cisplatin binding protein
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WebSep 1, 2024 · Cisplatin for injection, USP, a platinum-based drug for intravenous use, is a white to light yellow lyophilized powder. Each vial of Cisplatin for injection, USP contains … WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important.
WebMay 26, 2024 · Using the fluorescent cisplatin analog BODIPY-cisplatin, two-dimensional gel electrophoresis, and mass spectrometry, we identified the protein binding partners in A2780 and cisplatin-resistant A2780cis ovarian carcinoma, as well as in HCT-8 and oxaliplatin-resistant HCT-8ox colorectal cell lines. WebMay 15, 2016 · We summarize the structural features of known cisplatin-protein adducts. • Key characteristics of the cisplatin modes of binding to proteins are described. • …
WebApr 13, 2024 · HIGHLIGHTS. who: Florentine S. B. Subtil et al. from the Department of Radiotherapy and Radiooncology, Philipps-University, Marburg, Germany have published the research: Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines, in the … WebAug 2, 2016 · Our data reveal unexpected cisplatin binding sites on the protein surface that could have general significance: cisplatin fragments − [Pt (NH 3) 2 Cl] +, − [Pt (NH 3 )Cl 2 ], and − [Pt (NH 3) 2 (OH 2 )] 2+ …
WebDec 22, 2007 · D and E carboxylate oxygen atoms and M thioether sulfur atoms are kinetically preferred binding sites for cisplatin in competition with DNA nucleobase nitrogens, and it has been postulated that initial κ S coordination by methionine-containing proteins may play a role in the mechanism of the anticancer drug [ 14, 15 ].
WebFeb 1, 2016 · Cisplatin owns the most tendency to plasma proteins-so that after a few hours, up to 90% of the drug is bound to protein [19, 20]. Carboplatin possesses the … fletcher book seriesWebC-terminal binding protein‑2 (CtBP2) is a transcriptional co-repressor that is associated with tumorigenesis and tumor progression. It has been reported to predict a poor prognosis in several human cancers, including esophageal squamous cell fletcher boxspringWebJan 14, 1994 · Cisplatin-DNA adducts bind several cellular proteins, including some that enhance survival of the cell by mediating DNA repair and others that hasten its death by conferring sensitivity to the drug. Publication types Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review MeSH terms Animals Apoptosis / drug effects fletcher bowron mayorWebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … chelli meaning in tamilWebThe combination of adenoviruses and chemotherapy agents is a novel approach for human cancer therapeutics. A meticulous analysis between adenovirus and chemotherapeutic … fletcher branch library fletcher ncWebCisplatin is administered to cancer patients intravenously as a sterile saline solution (that is, containing salt—specifically, sodium chloride). Once cisplatin is in the … chelli motherwayWebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cisplatin response, and determined the expression of … fletcher brachytherapy